Clinical Takeaways

• The Reality Check: You cannot increase your Ovarian Reserve (quantity), but you can support Oocyte Competence (quality).
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• The "Big Three" Evidence-Based Supplements: Coenzyme Q10 (Ubiquinol), Vitamin D, and Methylfolate are the gold standard.

In the age of social media wellness, patients often arrive at our clinic overwhelmed and confused. At Ovom Care, we want to simplify this for you.

There is a significant difference between "wellness marketing" and clinical efficacy. While no pill can pause the biological clock, specific, evidence-backed compounds can improve the cellular environment in which your eggs mature.

At Ovom, we believe in data-backed fertility care. We don't guess; we look at the biochemistry. Here is what the science actually says about improving egg quality.

The Biology: Can You Really Change Egg Quality?

First, a critical distinction: You cannot change your Ovarian Reserve (the number of eggs remaining). That is determined at birth.

However, you can support Oocyte Competence (the egg's ability to mature, fertilize, and create a healthy embryo).

Every egg undergoes a maturation process called folliculogenesis that takes over  approximately 300 days before ovulation or retrieval. During this window, the egg is energy-hungry and highly vulnerable to its environment.

• The Goal: To protect the egg’s DNA and mitochondria (energy packs) from oxidative stress.
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• The Strategy: We focus on mitochondrial function and inflammation reduction during this 3-month window.

The "Big Three": Supplements with Real Clinical Data

If you are preparing for Egg Freezing or IVF, these are the three compounds supported by clinical data.

1. Coenzyme Q10 (Ubiquinol)

If you take only one supplement for fertility, this is the one supported by the most robust data.

The Science: Eggs require massive amounts of energy to divide chromosomes correctly. CoQ10 is cofactor for the mitochondria, or the powerhouses of the cell. As we age, mitochondrial function naturally declines, which is a leading cause of "chromosomal errors" (aneuploidy) in embryos.

‍Best absorption: The Ubiquinol form (the active antioxidant form) is significantly better absorbed by the body than the cheaper Ubiquinone. The target dosage is typically 400mg–600mg daily (divided doses), but always speak to your doctor.

2. NAD+ (Nicotinamide Adenine Dinucleotide)

NAD+ (Nicotinamide Adenine Dinucleotide) is a helper molecule found in every single cell of your body. You can think of it as the fuel that keeps your cells running. It is made naturally by your body from Vitamin B3 and proteins in your diet.

The Science Made Simple: Your eggs are very special cells because they require a huge amount of energy to mature, fertilize, and become an embryo. This energy is created in the "power plants" of your cells, called mitochondria.

NAD+ is the spark plug for those power plants. It helps move energy around so your cells can use it (Li et al., 2022).

Why it matters for Egg Freezing & IVF: Here is the catch: As we get older, our natural NAD+ levels drop. Boosting NAD+ through supplements can help "recharge" the mitochondria in your eggs. This ensures they have the energy they need to grow and the ability to repair their own DNA, which is essential for creating healthy embryos.

3. Rapamycin

Think of Rapamycin as a deep-cleaning service for your ovaries. It encourages your cells to clear out old, damaged debris and focus on repair, which helps slow down the aging process and keeps your eggs healthier for longer (Li et al., 2022).

The Lifestyle "Supplements" (That Are Free)

No pill can out-work a poor biological environment. Before spending money on supplements, optimize these three factors:

1. Blood Sugar Stability: Insulin resistance creates inflammation that can degrade egg quality. A diet rich in protein, fats, and complex carbs (minimizing sugar spikes) is arguably more powerful than any pill.
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2. Melatonin & Sleep: Melatonin is a powerful antioxidant that protects eggs. You produce it naturally when you sleep in total darkness. Prioritize 7-8 hours of sleep in a cool, dark room.
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3. Toxicant Removal: Endocrine disruptors (like BPA in plastics and phthalates in fragrances) can mimic hormones in the body. Switching to glass containers and fragrance-free products reduces the chemical load your eggs are exposed to.

FAQ: Common Questions on Fertility Supplements

Can supplements reverse egg aging?

‍No supplement can turn back time or generate new eggs. However, they can help the eggs you have remaining to be "chromosomally normal" (euploid), increasing the chance they result in a healthy baby.

Should my male partner take supplements too?

‍Absolutely. Male factor infertility is involved in up to 50% of cases. Men should consider a regimen including a multivitamin, Zinc, Selenium, and CoQ10 to support sperm DNA integrity.

The Ovom Difference

At Ovom, we do not hand out generic "one-size-fits-all" fertility packs. We test your blood for micronutrient deficiencies, hormonal baselines, and genetic markers first.Your supplement plan should be as unique as your DNA.

Ready to build a plan based on your data? Book a Consultation with us.

Footnotes:

1. Li H, Wang H, Xu J, Zeng X, Sun Y, Yang Q. Nicotinamide riboside supplementation ameliorated post-ovulatory oocyte quality decline. Reproduction. 2022 Dec 2;165(1):103-111. doi: 10.1530/REP-22-0095. PMID: 36269127.